A Pragmatic Randomized trial Evaluating Pre-operative aqueous antiseptic skin solutions in open fractures

McMaster Led

PI: Gerard Slobogean, Sheila Sprague, Mohit Bhandari

Local PI: Brad Petrisor

Project Coordinator: Jodi Gallant (

Status: Complete

Recruitment Start Date: April 2018

Recruitment End Date: April 2020

Objective: To compare the effectiveness of aqueous pre-operative antiseptic skin preparation with 10% povidone-iodine versus 4% chlorhexidine gluconate (CHG) for the management of open fractures. A ranked order for assessing effectiveness will be used with surgical site infection (SSI) as the primary comparison and unplanned fracture-related reoperations as the secondary comparison.


Summary Poster –

The Lancet Paper –

Funding Received: Physician’s Services Incorporated Foundation, McMaster Surgical Associates, the United States Department of Defense (DoD), and the Canadian Institutes of Health Research (CIHR)

Anatomical Location: Open fractures of the appendicular skeleton.