Aqueous-PREP – A Pragmatic Randomized trial Evaluating Pre-operative aqueous antiseptic skin solutions in open fractures
A Pragmatic Randomized trial Evaluating Pre-operative aqueous antiseptic skin solutions in open fractures
PI: Dr. Gerard Slobogean, Dr. Sheila Sprague, Dr. Mohit Bhandari
Local PI: Dr. Brad Petrisor
Project Coordinator: Jodi Gallant (firstname.lastname@example.org)
Recruitment Start Date: April 2018
Recruitment End Date: April 2020
Objective: To compare the effectiveness of aqueous pre-operative antiseptic skin preparation with 10% povidone-iodine versus 4% chlorhexidine gluconate (CHG) for the management of open fractures. A ranked order for assessing effectiveness will be used with surgical site infection (SSI) as the primary comparison and unplanned fracture-related reoperations as the secondary comparison.
The Lancet Paper – https://authors.elsevier.com/c/1fvof_3CjG880q
Funding Received: Physician’s Services Incorporated Foundation, McMaster Surgical Associates, the United States Department of Defense (DoD), and the Canadian Institutes of Health Research (CIHR)
Anatomical Location: Open fractures of the appendicular skeleton.