A Pragmatic Randomized trial Evaluating Pre-operative aqueous antiseptic skin solutions in open fractures

McMaster Led

PI: Dr. Gerard Slobogean, Dr. Sheila Sprague, Dr. Mohit Bhandari

Local PI: Dr. Brad Petrisor

Project Coordinator: Jodi Gallant (gallaj4@mcmaster.ca)

Status: Complete

Recruitment Start Date: April 2018

Recruitment End Date: April 2020

Objective: To compare the effectiveness of aqueous pre-operative antiseptic skin preparation with 10% povidone-iodine versus 4% chlorhexidine gluconate (CHG) for the management of open fractures. A ranked order for assessing effectiveness will be used with surgical site infection (SSI) as the primary comparison and unplanned fracture-related reoperations as the secondary comparison.

Results:

Summary Poster – https://www.motr.ca/wp-content/uploads/2022/03/A-PREP-Results-Poster.pdf

The Lancet Paper – https://authors.elsevier.com/c/1fvof_3CjG880q

Funding Received: Physician’s Services Incorporated Foundation, McMaster Surgical Associates, the United States Department of Defense (DoD), and the Canadian Institutes of Health Research (CIHR)

Anatomical Location: Open fractures of the appendicular skeleton.