Conflict of Interest Disclosures: Dr Slobogean reported receiving grants from Patient-Centered Outcomes Research Institute and the US Department of Defense during the conduct of the study; personal fees from Zimmer Biomet and Smith & Nephew outside the submitted work. Dr Sprague reported receiving grants from Patient-Centered Outcomes Research Institute, Canadian Institutes of Health Research, the US Department of Defense, McMaster University Surgical Associates, and The Physicians Services Incorporated during the conduct of the study; personal fees from Global Research Solutions, University of Sherbrooke, Dartmouth University, and University of Maryland outside the submitted work. Dr Bhandari reported receiving grants from Patient-Centered Outcomes Research Institute, Canadian Institutes of Health Research, the US Department of Defense, and Physicians Services Incorporated during the conduct of the study; personal fees from Smith & Nephew, Stryker, Amgen, Zimmer, Moximed, Bioventus, Merck, Eli Lilly, Sanofi, Ferring, and Conmed outside the submitted work; and grants from Smith & Nephew, DePuy, Eli Lily, Bioventus, Stryker, Zimmer, and Amgen outside the submitted work. Dr Rojas reported receiving grants from Physicians Services Incorporated during the conduct of the study. Ms Wood reported receiving honoraria from University of Maryland during the conduct of the study; and receiving personal fees from Bush Ross outside the submitted work. Dr Harris reported serving as an advisory board member for Entasis; and serving as the infection control section editor for UptoDate outside the submitted work. Dr Petrisor reported receiving grants from Canadian Institutes of Health Research during the conduct of the study. Dr Mullins reported receiving grants from Patient-Centered Outcomes Research Institute during the conduct of the study; personal fees and nonfinancial support from AstraZeneca, Bayer, Boehringer-Ingelheim, Illumina, Janssen/J&J, Merck, Pfizer, Regeneron, and Sanofi outside the submitted work. Ms Heels-Ansdell reported receiving grants from Patient-Centered Outcomes Research Institute, the US Department of Defense, and Canadian Institutes of Health Research during the conduct of the study. Ms Del Fabbro reported receiving grants from Physicians’ Services Incorporated and McMaster Surgical Associates during the conduct of the study. Dr Della Rocca reported receiving personal fees from DePuy-Synthes; and having stock options from The Orthopaedic Implant Company, Mergenet Medical, and Intellectual Ventures outside the submitted work. Dr Gitajn reported receiving personal fees from Stryker outside the submitted work. Mr Friedrich reported receiving an honorarium from University of Maryland during the conduct of the study. Mr Rudnicki reported receiving grants from Patient-Centered Outcomes Research Institiute and the US Department of Defense during the conduct of the study. Dr Jeray reported receiving consulting fees from ZimmerBiomet; presentation fees from Radius; and research funding from AO North America outside the submitted work. Dr Joshi reported receiving grants from University of Maryland during the conduct of the study; and grants from the US Department of Defense and Patient-Centered Outcomes Research Institiute outside the submitted work. Ms Camara reported receiving grants from the US Department of Defense and Patient-Centered Outcomes Research Institute during the conduct of the study. Dr Szasz reported receiving grants from Physician’s Services Incorporated and McMaster Surgical Associates during the conduct of the study. Mr N. O’Hara reported receiving grants from Patient-Centered Outcomes Research Institute and the US Department of Defense during the conduct of the study; stock options from Arbutus Medical Inc; and grants from Osteosynthesis and Trauma Care Foundation outside the submitted work. Ms McKay reported receiving grants from University of Maryland during the conduct of the study; and personal fees from Global Resaarch Solutions outside the submitted work. Dr Devereaux reported receiving grants from Abbott Diagnostics, Boehringer Ingelheim, Philips Healthcare, and Roche Diagnostics; and grants and nonfinancial support from Siemens outside the submitted work. Dr O’Toole reported receiving grants from Patient-Centered Outcomes Research Institute and the US Department of Defense during the conduct of the study; personal fees from Smith & Nephew Consultant; consulting fees and stock from Imagen; and personal fees and personal fees and royalties from Coorstek outside the submitted work. Dr Zura reported receiving personal fees from Bioventus and Smith & Nephew and Osteocentric outside the submitted work. Dr Tanner reported receiving grants from the US Department of Defense and Patient-Centered Outcomes Research Institute during the conduct of the study. No other disclosures were reported.